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Results for "

CFTR corrector

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (22) Autophagy (4)
By Research Areas:	Cancer (3) Endocrinology (4) Inflammation/Immunology (12) Metabolic Disease (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: CFTR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135279

CFTR corrector 4	CFTR	Inflammation/Immunology
CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis .

HY-136939

CFTR corrector 6	CFTR	Metabolic Disease Inflammation/Immunology
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research .

HY-125381

CFTR corrector 2 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology Cancer
CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933 .

HY-153133

CFTR corrector 11

CFTR Others

CFTR corrector 11 (compound 133) is a CFTR corrector .

CFTR corrector 11	CFTR	Others
CFTR corrector 11 (compound 133) is a *CFTR* corrector .

HY-155742

CFTR corrector 12	CFTR	Others
CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells .

HY-147315

CFTR corrector 9	CFTR	Others
CFTR corrector 9 (compound 42) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. CFTR corrector 9 can be used for researching cystic fibrosis (CF) and other CFTR associated disorders .

HY-147249

CFTR corrector 8

CFTR Inflammation/Immunology

CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis .
HY-158002

IDOR-4

CFTR Inflammation/Immunology

IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .
HY-158144

GLPG2737

CFTR Others

GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis .

CFTR corrector 8	CFTR	Inflammation/Immunology
CFTR corrector 8 is a potent *CFTR* modulator. CFTR can be used in the research of cystic fibrosis .

IDOR-4	CFTR	Inflammation/Immunology
IDOR-4 is a type IV *CFTR* corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .

GLPG2737	CFTR	Others
GLPG2737 is a potent *CFTR* type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis .

HY-13262

Lumacaftor Maximum Cited Publications 12 Publications Verification VX-809; VRT 826809	CFTR Autophagy	Inflammation/Immunology
Lumacaftor (VX-809; VRT 826809) is a *CFTR* modulator that corrects the folding and trafficking of CFTR protein.

HY-109187A

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

HY-109187

Posenacaftor PTI-801	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-15448

Tezacaftor 5+ Cited Publications VX-661	CFTR	Cancer
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-109187B

(R)-Posenacaftor sodium (R)-PTI-801 sodium	CFTR	Inflammation/Immunology
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-15448S

Tezacaftor-d4 VX-661-d₄	CFTR Autophagy	Cancer
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps *CFTR* protein reach the cell surface .

HY-126394B

Bamocaftor potassium VX-659 potassium	CFTR	Endocrinology
Bamocaftor potassium is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore *F508del-CFTR* protein function. Bamocaftor potassium can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-19970

KM11060 2 Publications Verification	CFTR Autophagy	Endocrinology
KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research .

HY-126394

Bamocaftor VX-659	CFTR	Endocrinology
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore *F508del-CFTR* protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent *CFTR* Cl ^- channel potentiator. PG01 can correct gating defects of *CFTR* mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases *ΔF508-CFTR* Cl ^- current after adding Forskolin .

HY-133013

GLPG-3221	CFTR	Inflammation/Immunology
GLPG-3221 is a potent, orally active corrector of *CFTR* (cystic fibrosis transmembrane conductance regulator), with an EC₅₀ of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis .

HY-111111

Galicaftor 1 Publications Verification ABBV-2222; GLPG-2222	CFTR	Inflammation/Immunology
Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research .

HY-15448A

(Rac)-Tezacaftor (Rac)-VX-661	CFTR	Inflammation/Immunology
(Rac)-Tezacaftor ((Rac)-VX-661) is a racemate of Tezacaftor (HY-15448). Tezacaftor is a F508del CFTR corrector. (Rac)-Tezacaftor can be used for the research of cystic fibrosis .

Tezacaftor-d4
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps *CFTR* protein reach the cell surface .

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